Active Histone Deacetylases, Active Kinases, Active Phosphatases, Active Phosphodiesterases
Isoform Specific Antibodies, Primary Antibodies, Secondary Antibodies, Tag Antibodies
Cell Signaling Reagents
Cellular Proteins, Peptide Substrates, Reagents Sirtuin Proteins, Unactive Kinases
Compound Selectivity Profiling, Custom Protein Development
Recent Newsletter Articles
UCell Death and Immune Response (Volume 9, Issue 1)
The contributions of different cell death mechanisms to avoid cancer or degenerative diseases remain to be defined. Particularly in cancer, where defects in cell death are widespread and promote tumor progression and treatment resistance. The restoration of cell death pathways in these conditions is an important therapeutic goal. Moreover, distinct cell death modalities may remain immunologically silent or trigger an immune response, by mechanisms that are still unknown. The regulations and the pathogenic dysfunctions of distinct cell death mechanisms and immune responses present new therapeutic strategies against cancer cell induction.
Colon Cancer Biology (Volume 8, Issue 6)
Colon Cancer is the second commonest cause of cancer mortality and the third commonest cause of cancer in the western world. Several environmental factors are recognized to increase its incidence such as increased red meat and saturated fat consumption, as well as a sedentary occupation with a corresponding lack of physical activity. Notably, colorectal cancer (CRC) is one where screening has had, and will continue to have, an extraordinarily large role to play; timely colonoscopy in patients shown to have occult (unseen) bleeding, with removal of polyps has been shown to significantly reduce mortality. However, almost 50% of patients with CRC present at an advanced stage, prompting the need for better understanding its biology.
Research Milestone-Highly Active Sirtuins (Volume 8, Issue 5)
Sirtuins are class III histone deacetylases that have a NAD+ deacetylase and/or ADP-ribosyl transferase activity. The 7 members of sirtuins (SIRT1 through SIRT7) post-translationally modify a number of cellular proteins, affecting cell cycle regulation, cell differentiation, genomic stability, tumorigenesis, oxidative stress response, energy metabolism and other cellular processes. Although there is no direct evidence for the role of sirtuins in extending lifespan in mammals, various mouse models show that small molecules targeting SIRT proteins may treat age-associated diseases including diabetes, cancer and cardiac dysfunction.