Search SignalChem:   1-866-9 KINASE (54-6273)

Products Discovery Services Promotions Distribution Support Corporate Ordering

home  products  IRR, Active (I07-11G) Catalog Number Pack Size Price (US) I07-11G-05 5 μg  $195  I07-11G-10 10 μg  $285  I07-11G-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant human IRR (945-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.   Genbank Number: NM_014215   Sequence: 945-end   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~65 kDa Gene Aliases: INSRR Scientific Background: IRR or insulin receptor-related receptor is a tyrosine protein kinase that is required for the appearance of male gonads and thus for male sexual differentiation (1). The expression of IRR mRNA is restricted to a few tissue types and has been detected in neuronal tissues as well as in neuroblastomas. As a result of its occurrence in neuroblastomas, it has speculated that IRR may be involved in tumor genesis. RT-PCR and solution hybridization/RNAse protection assay have shown strong coupling of IRR mRNA in 18 tumor cell lines (2). References:  1. Zhang, B. and Roth, R.A. The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities. J. Biol. Chem. 1992; 267 (26): 18320-8. 2. Elmlinger, M.W. et al: Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin. Regul. Pept., 1999; 84 (1-3): 37-42.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Bulk Orders   SAME QUALITY... BETTER RATES SignalChem provides all of its products in custom pack sizes to meet your discovery needs. more info           Custom Proteins   RELIABLE SERVICE...                 QUALITY RESULTS SignalChem has extensive experience in the development and production of high quality protein 'targets'. Expertise includes: cloning, expression and activation of signaling proteins. more info           Profiling Services   EFFICIENT PROCESS...      FAST TURNAROUND TIME SignalChem understands that timelines are of critical importance. We commit to providing our partners with a fully customized inclusive report within a 2-week time period. more info

Contact SignalChem [toll free]: 1-866-9 KINASE (54-6273) [phone]: 1-604-232-4600 [fax]: 1-604-232-4601 [email]: info@signalchem.com

Products  |   Discovery Services  |   Promotions  |   Distribution  |   Support  |   Corporate  |   Ordering Site By: Irtus Software