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home  products  BAX Protein (B14-30G) Catalog Number Pack Size Price (US) B14-30G-50 50 μg  $285  B14-30G-200 200 μg  $795    15% OFF   Product Description     Data Sheets     Related Products     Description: Recombinant full-length human BAX was expressed in E. coli cells using an N-terminal GST tag.   Genbank Number: NM_004324   Sequence: Full-length   Expression System: E.coli   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Western Blot Molecular Weight: ~49 kDa Scientific Background: BAX is a proapoptotic protein of the BCL2 protein family. BAX forms a heterodimer with BCL2 and functions as an apoptotic activator. BAX interacts with and increases the opening of the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in the mitochondrial membrane potential and the release of cytochrome c (1). The expression of BAX gene is regulated by the tumor suppressor p53 and BAX has been shown to be involved in p53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene (2). References:  1. Shimizu, S. et al: Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399: 483-487, 1999. 2. Meijerink, J. P. P. et al : Hematopoietic malignancies demonstrate loss-of-function mutations of BAX. Blood 91: 2991-2997, 1998.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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