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home  products  AKT2, Unactive (A17-15H) Catalog Number Pack Size Price (US) A17-15H-20 20 μg  $195  A17-15H-50 50 μg  $395    Product Description     Data Sheets     Related Products     Description: Recombinant human AKT2 (142-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.   Genbank Number: NM_001626.   Sequence: 142-end   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal His tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~41kDa Gene Aliases : PRKBB; PKBBETA; RAC-BETA Scientific Background: AKT2 or Protein Kinase B β (PKBβ) is a serine/threonine kinase that is a member of the AKT family. AKT2 like the other AKT members is activated in cells in response to diverse stimuli such as hormones, growth factors and extracellular matrix components and is involved in glucose metabolism, transcription, survival, cell proliferation, angiogenesis, and cell motility (1). The PI3K generates phosphatidylinositol-3, 4, 5-trisphosphate (PIP3), a lipid second messenger essential for the translocation of AKT2 to the plasma membrane where it is phosphorylated and activated by phosphoinositide-dependent kinase-1 (PDK-1) (2). References:  1. Coffer, PJ. et al: Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J. 1998 Oct 1; 335 ( Pt 1):1-13. 2. Anderson, KE. et al: Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr Biol. 1998 Jun 4;8(12): 684-91.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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