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| Catalog Number |
Pack Size |
Price (US) |
| R02-11G-05 |
5 μg |
$195
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| R02-11G-10 |
10 μg |
$285
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| R02-11G-20 |
20 μg |
$495
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Description: Recombinant human RET (658-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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Genbank Number:
NM_020630
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Sequence:
658-end
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Expression System:
Sf9 insect cells using baculovirus
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Tag:
N-terminal GST tag
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Species:
Human
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Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications: Kinase Assay, Western Blot
Molecular Weight: ~74 kDa
Gene Aliases : PTC, MTC1, HSCR1, MEN2A, MEN2B, RET51, CDHF12, RET-ELE1
Scientific Background: RET gene codes for a transmembrane tyrosine kinase which is a subunit of a multimeric complex that acts as a receptor for four structurally related molecules: GDNF, neurturin, artemin and persephin (1). Germline mutations of RET cause a dominantly inherited dysgenesis of the enteric nervous system known as Hirschsprung's disease. RET is constitutively activated by point mutations in hereditary medullary thyroid carcinomas (MTCs). Several single nucleotide polymorphisms of the RET gene have been described. Multiple endocrine neoplasia type 2A (MEN 2A) have been reported to be associated with two mutations of the protooncogene RET (2).
References:
1. Geneste, O. et al: Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site. Hum Mol. Genet. 1999; 8(11):1989-99.
2. Kahn, Tessitore, A. et al: A novel case of multiple endocrine neoplasia type 2A associated with two de novo mutations of the RET protooncogene. J. Clin. Endocrinol. Metab. 1999; 84(10):3522-7.
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Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet. |
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Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet. |
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SAME QUALITY...
BETTER RATES
SignalChem provides all of its products in
custom pack sizes to meet your discovery needs.
more info |
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RELIABLE SERVICE...
QUALITY RESULTS
SignalChem has extensive experience in the development
and production of high quality protein 'targets'. Expertise
includes: cloning, expression and activation of signaling proteins.
more info |
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EFFICIENT PROCESS...
FAST TURNAROUND TIME
SignalChem understands that timelines are of critical
importance. We commit to providing our partners with a fully customized inclusive report within a 2-week time period.
more info |
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