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home  products  Anti-AMPKα1/2 (P47-63BR) Catalog Number Pack Size Price (US) P47-63BR-100 100 μg  $245    15% OFF   Product Description     Data Sheets     Related Products     Description: Rabbit Polyclonal Antibody Specificity: Recognizes the AMPK1 and AMPK2 protein Cited Applications: WB Cross Reactivity: Western blot human AMPK1 and AMPK2 AMPK1 and AMPK2 from other species may also be detectable Host: Rabbit Immunogen: Synthetic peptide corresponding to amino acids 170-174 of human AMPK Formulation: PBS pH 7.4, 0.02% sodium azide, 50% glycerol Purification: Affinity chromatography Stability: Store at 40oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot antibody into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles. Scientific Background: AMP-activated protein kinase (AMPK) exhibits a key role as a master regulator of cellular energy homeostasis (1). AMPK exists as a heterotrimeric complex composed of a catalytic α subunit and regulatory β and γ subunits. Binding of AMP to the γ subunit allosterically activates the complex. AMPK is activated in response to stresses that deplete cellular ATP (low glucose, hypoxia and ischemia) (2) and via signaling pathways in response to adiponectin, leptin and CAMKKβ. References:  1. Hardie, G.D. The AMP-activated protein kinase pathway – new players upstream and downstream. J. Cell Sci. 2004;117: 5479–5487. 2. Kahn, B.B. et al. AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab; 2005: 1, 15–25.   Sample Data:  Representative western blot with Anti-AMPK1/2 (1:1000) using 20 ng of human recombinant AMPK1 and AMPK2.

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