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home  products  Anti-DOK1 (D42-63R) Catalog Number Pack Size Price (US) D42-63R-100 100 μg  $245    15% OFF   Product Description     Data Sheets     Related Products     Description: Rabbit Polyclonal Antibody Specificity: Recognizes the DOK1 protein Cited Applications: WB Cross Reactivity: Western blot DOK1 from human and mouse cells DOK1 from other species may also be detectable Host: Rabbit Immunogen: Synthetic peptide corresponding to amino acids 360-364 of human DOK1 (Q99704) Formulation: PBS pH 7.4, 0.02% sodium azide, 50% glycerol Purification: Affinity chromatography Stability: Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Scientific Background: DOK1 contains pleckstrin homology domain and ten PXXP SH3 recognition motifs and is a critical substrate for p210 bcr/abl. DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors cells isolated from CML patients (1). DOK1 is associated with p120 Ras-GAP and this association is correlated with its tyrosine phosphorylation. Aberrant phosphorylation of DOK1 may contribute to the progression of different human diseases (2). References:  1. Carpino, N. et.al: p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 88: 197-204, 1997. 2. Yasuda. et.al: Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J. Exp. Med. 200: 1681-1687, 2004. For specific information on a given lot, see related technical data sheet :    Sample Data :  Representative western blot with Anti-DOK1 (1:1000) using 3 μg, 10 μg and 30 μg of 3T6 cell lysate.

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