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home  products  Anti-UBC9 (U19-63R) Catalog Number Pack Size Price (US) U19-63R-100 100 μg  $245    15% OFF   Product Description     Data Sheets     Related Products     Description: Rabbit Polyclonal Antibody Specificity: Recognizes the UBC9 protein Cited Applications: WB Cross Reactivity: Western blot UBC9 from human and mouse cells UBC9 from other species may also be detectable Host: Rabbit Immunogen: Synthetic peptide of c-terminal amino acid sequence of human UBC9 (P63279) Formulation: TBS, 50% glycerol Purification: Affinity chromatography Stability: Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Scientific Background: UBC9 is a member of the E2 ubiquitin-conjugating enzyme family that is involved in ubiquitin-dependent protein degradation system (1). Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes and ubiquitin-protein ligases. UBC9 can function as a co-factor of PLAGL2, uncoupling its enzymatic activity to mediate PLAGL2 interactive SP-C promoter activity (2). UBC9 also plays an important role in the up-regulation of the bone morphogenetic protein signaling pathway. References:  1. Yasugi, T. et.al: Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9. Nucleic Acids Res. 24: 2005-2010, 1996. 2. Wang, Z.-Y. et.al: Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9. J. Biol. Chem. 271: 24811-24816, 1996. For specific information on a given lot, see related technical data sheet :    Sample Data :  Representative western blot with Anti-UBC9 (1:1000) using 3 μg, 10 μg and 30 μg of Jurkat cell lysate.

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