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home  products  RhoA Protein (R44-30H) Catalog Number Pack Size Price (US) R44-30H-50 50 μg  $145  R44-30H-200 200 μg  $345    15% OFF   Product Description     Data Sheets     Related Products     Description: Recombinant full length human RhoA was expressed in E. coli cells using an N-terminal His tag.   Genbank Number: NM_001664   Sequence: Full-length   Expression System: E.coli   Tag: N-terminal His tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~23 kDa Gene Aliases : ARH12; ARHA; RHO12; RHOH12 Scientific Background: RhoA is a member of the Rho gene family that interacts with protein kinases and serves as a target of activated GTPase. RhoA play an important role in the initial events of cell protrusion, whereas Rac1 and Cdc42 activate pathways implicated in reinforcement and stabilization of newly expanded protrusions. Rho mediates corneal epithelial migration in response to external stimuli by regulating the organization of the actin cytoskeleton (1). The inhibition of RhoA signaling is required for both vaccinia morphogenesis and virus-induced cell motility. Vaccinia inhibits RhoA signalling using the viral protein F11 and this can enhance the spread of infection (2). References:  1. Wu, K. Y.et.al: Local translation of RhoA regulates growth cone collapse. Nature 436: 1020-1024, 2005. 2.Valderrama, F.et.al: Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling. Science 311: 377-381, 2006.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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