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home  products  PDE1B, Active (P89-30BG) Catalog Number Pack Size Price (US) P89-30BG-05 5 μg  $235  P89-30BG-10 10 μg  $345  P89-30BG-20 20 μg  $555    Product Description     Data Sheets     Related Products     Description: Full-length recombinant human PDE1B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.   Genbank Number: NM_000924   Sequence: Full-length   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: PDE Assay Molecular Weight: ~86 kDa Gene Aliases : PDE1B1; PDES1B Scientific Background: PDE1B is a member of the PDE protein superfamily that catalyzes the hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. PDE1B is a calmodulin-dependent enzyme that is stimulated by calcium-calmodulin complex (1). PDE1B is express in the lymphoblastic and leukemic cell lines and causes the cells to undergo apoptosis, suggesting PDE1B could be a novel therapeutic strategy for the treatment of leukemia (2). GM-CSF is a major regulator of monocyte to macrophage differentiation and this cytokine has been shown to up-regulate PDE1B. References:  1. Yu, J.et.al: Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1. Cell. Signal. 9: 519-529, 1997. 2. Jiang, X. et.al: Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells. Proc. Nat. Acad. Sci. 93: 11236-11241, 1996.   Specific Activity:  Sample Phosphodiesterase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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