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home  products  CAMK4, Active (C15-10G) Catalog Number Pack Size Price (US) C15-10G-05 5 μg  $195  C15-10G-10 10 μg  $285  C15-10G-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant full-length human CAMK4 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.   Genbank Number: NM_001744   Sequence: Full-length   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~79 kDa Gene Aliases : CaMK-GR; MGC36771 Scientific Background: CAMK4 is a multifunctional serine/threonine protein kinase and a member of Ca(2+)/calmodulin- dependent protein kinase family. CAMK4 is localized in neurons in the hippocampus, amygdala, anterior cingulate cortex, somatosensory cortex, and insular cortex (1). CAMK4 is involved in neural activity-dependent signaling in the neuronal nucleus and thought to plays an important role in the consolidation/retention of hippocampus-dependent long-term memory (2). References:  1. Sikela, J. M. et al: Chromosomal localization of the human gene for brain Ca(2+)/calmodulin-dependent protein kinase type IV. Genomics 4: 21-27, 1989. 2. Kang, H. et al: An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory. Cell 106: 771-783, 2001.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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