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home  products  RAS Protein (R05-30G) Catalog Number Pack Size Price (US) R05-30G-50 50 μg  $195  R05-30G-200 200 μg  $395    15% OFF   Product Description     Data Sheets     Related Products     Description: Recombinant full-length human RAS was expressed in E. coli cells using a N-terminal GST tag.   Genbank Number: NM_ 005343   Sequence: Full-length   Expression System: E. coli   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~47 kDa Gene Aliases: K-ras; N-ras; RASH1; c-bas/has Scientific Background: The RAS gene superfamily encodes a group of closely related 21,000 dalton (p21) proteins with special affinity for guanine nucleotides (GTP). RAS and several other cellular proteins with similar biochemical properties are collectively known as G-proteins and they play key roles in a wide variety of cellular activities, including cell growth, differentiation, secretion, and protein trafficking (1). There are three forms of RAS gene in cells termed H-RAS, N-RAS, and K-RAS. RAS proteins play a direct causal role in human cancer and in other diseases. Mutant H-RAS, N-RAS, and K-RAS occur in varying frequencies in different tumor types (2). Other members of the RAS superfamily may also contribute to cancer. References:  1. Shih, T. Y., et al: Structure and function of p21 ras proteins. Gene Amplif Anal. 1986;4:53-72. 2. Rodriguez-Viciana, P.: Cancer targets in the Ras pathway. Cold Spring Harb Symp Quant Biol. 2005;70:461-7.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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