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home  products  ERK1, Active (M29-10U) Catalog Number Pack Size Price (US) M29-10U-05 5 μg  $195  M29-10U-10 10 μg  $285  M29-10U-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant full-length, tag-free human ERK1 was by baculovirus in Sf9 insect cells and activated by active MEK1in vitro.   Genbank Number: NM_002746   Sequence: Full-length   Expression System: Sf9 insect cells using baculovirus   Tag: tag-free   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~44 kDa Gene Aliases : MAPK3; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; MGC20180 Scientific Background: ERK1 is a protein serine/threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines (1). Activation of ERK1 requires both tyrosine and threonine phosphorylation that is mediated by MEK. ERK1 is ubiquitously distributed in tissues with the highest expression in heart, brain and spinal cord. Activated ERK1 translocates into the nucleus where it phosphorylates various transcription factors (e.g., Elk-1, c-Myc, c-Jun, c-Fos, and C/EBP beta). References:  1. Boulton, TG. et al: Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase. Biochemistry. 1991 Jan 8;30(1):278-86.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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