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home  products  categories  p38γ, Active (M37-10G) Catalog Number Pack Size Price (US) M37-10G-05 5 μg  $195  M37-10G-10 10 μg  $285  M37-10G-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant full-length human p38gamma was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.   Genbank Number: NM_002969   Sequence: Full-length   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~71 kDa Gene Aliases : ERK3; ERK6; SAPK3; PRKM12; MAPK12 Scientific Background: P38γ is a member of the p38 MAPK family which is activated in response to stress (1). p38γ gene was mapped to 22q13.3 and functions as a signal transducer during differentiation of myoblasts to myotubes. Enforced localization of p38γ in the nucleus or cytoplasm markedly attenuates the ability of the kinase to induce cell cycle arrest in fibroblasts. p38γ increases basal glucose uptake and decreases DNP- and contraction-stimulated glucose uptake, partially by affecting levels of glucose transporter expression in skeletal muscle (2). References:  1. Li, Z. et al: The primary structure of p38-gamma: a new member of p38 group of MAP kinases. Biochem. Biophys. Res. Commun. 228: 334-340, 1996. 2. Ho, RC. et al: p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2004 Feb; 286(2):R342-9. Epub 2003 Oct 30.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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