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home  products  categories  Anti-p53 (P05-63R) Catalog Number Pack Size Price (US) P05-63R-25 25 μg  $95    15% OFF P05-63R-100 100 μg  $245    $215   Product Description     Data Sheets     Related Products     Description: Rabbit Polyclonal Antibody   Species: Rabbit Specificity: Anti-p53 antibody recognizes the p53 protein. Cited Applications: WB Cross Reactivity: p53 from Human p53 from other species may also be detectable. Host: Rabbit Immunogen: Human p53 peptide-KLH conjugates Formulation: TBS at pH 7.2, 50% glycerol Purification: Affinity purified by p53 peptide on agarose from rabbit serum Stability: Store at 4°C (add 0.1% NaN3) for several months, and at -20°C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles. Scientific Background: p53 is a key regulator of cell growth and acts as a tumor suppressor gene. Wild-type p53 gene can suppress transformation of rat embryo fibroblasts in cell culture by other oncogenes such as the adenovirus E1A and Ras (1). DNA tumor viruses such as SV40 large T antigen and the adenovirus E1A plus E1B-55Kd proteins bind to p53 and inactivate its tumor suppressor activities leading to cellular transformation. Mutational inactivation of the p53 gene is detected in more than 50% of human cancers. Mutation of p53 renders cancer cells more resistant to current cancer therapies due to lack of p53-mediated apoptosis (2). References:  1. Levine, A J. et al: Tumor suppressor genes: the p53 and retinoblastoma sensitivity genes and gene products. Biochim Biophys Acta. 1990 Jun 1;1032(1):119-36. 2. Sun, Y. p53 and its downstream proteins as molecular targets of cancer. Mol Carcinog. 2006 Jun;45(6):409-15. For specific information on a given lot, see related technical data sheet:    Sample Immunoprecipitation:  Representative western blot using 5μg, 10μg, and 30μg, of HEK-293 cell lysate.

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