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home  products  categories  MAPKAPK2, Active (M40-11H) Catalog Number Pack Size Price (US) M40-11H-05 5 μg  $195  M40-11H-10 10 μg  $285  M40-11H-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant human MAPKAPK2 (46-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.   Genbank Number: NM_032960   Sequence: 46-end   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal His tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~41kDa Gene Aliases : (2 isoforms) Scientific Background: MAPKAPK2 (MAPKAP kinase2) is a Ser/Thr protein kinase which is regulated via direct phosphorylation by p38 MAP kinase (1). In conjunction with p38 MAP kinase, MAPKAPK2 is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 has been shown to be one of the substrates of MAPKAPK2, in vivo. References:  1. Stokoe, D. et al: The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. Biochem. J. 296: 843-849, 1993.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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