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| Catalog Number |
Pack Size |
Price (US) |
| M39-63R-25 |
25 μg |
$115
 15% OFF
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| M39-63R-100 |
100 μg |
$315
15% OFF
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Description: Rabbit Polyclonal Antibody |
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Specificity: Recognizes the p38α protein
Cited Applications: WB
Cross Reactivity: Western blot human p38α
p38α from other species may also be detectable.
Host: Rabbit
Immunogen: C-terminal peptide of p38α conjugated to ovalbumin
Formulation: TBS at pH 7.2, 50% glycerol
Purification: Affinity chromatography
Stability: Store at 4°C (add 0.1% NaN3) for several months, and at -20°C for longer periods.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Scientific Background: p38α (SAPK2A) is a member of the p38 MAPK family which are activated by various environmental stresses and proinflammatory cytokines (1). The activation of p38 requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase (2). The substrates of p38 include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response (5).
References: 1. Han, J. et al: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811, 1994.
2. Ge, B. et al: MAPKK-independent activation of p38-alpha mediated by TAB1-dependent autophosphorylation of p38-alpha. Science 295: 1291-1294, 2002.
For specific information on a given lot, see related technical data sheet:
gel.jpg) |
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Sample Western Blot:
Representative western blot (1:1000) using 20ng of p38α, p38β, p38γ, and p38δ recombinant protein. |
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SAME QUALITY...
BETTER RATES
SignalChem provides all of its products in
custom pack sizes to meet your discovery needs.
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RELIABLE SERVICE...
QUALITY RESULTS
SignalChem has extensive experience in the development
and production of high quality protein 'targets'. Expertise
includes: cloning, expression and activation of signaling proteins.
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EFFICIENT PROCESS...
FAST TURNAROUND TIME
SignalChem understands that timelines are of critical
importance. We commit to providing our partners with a fully customized inclusive report within a 2-week time period.
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