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home  products  categories  Anti-Rel A (R29-63R) Catalog Number Pack Size Price (US) R29-63R-100 100 μg  $245    15% OFF   Product Description     Data Sheets     Related Products     Description: Rabbit Polyclonal Antibody Specificity: Recognizes the Rel A protein Cited Applications: WB Cross Reactivity: Western blot of human and mouse Rel A Rel A from other species may also be detectable Host: Rabbit Immunogen: Synthetic peptide corresponding to amino acids 274-278 of human Rel A Formulation: PBS pH 7.4, 0.02% sodium azide, 50% glycerol Purification: Affinity chromatography Stability: Store at 4°C (add 0.1% NaN3) for several months, and at -20°C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles. Scientific Background: Transcription factors of the nuclear factor κB (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses In unstimulated cells, NF-κB is sequestered in the cytoplasm by its inhibitory proteins, the IκBs (1). NF-κB-activating agents can induce the phosphorylation of IκB’s, targeting them for rapid degradation through an ubiquitin-proteasome pathway, releasing NF-κB to enter the nucleus, where it regulates gene expression. References:  1. Baeuerle, P. et al: Function and activation of NF-kappa B in the immune system. Annu Rev Immunol. 1994;12:141-79. For specific information on a given lot, see related technical data sheet :    Sample Data :  Representative western blot with Anti-Rel A (1:1000) using 3 μg , 10 μg , and 30 μg of cell lysate.

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