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home  products  categories  MAPKAPK2, Unactive (M40-14G) Catalog Number Pack Size Price (US) M40-14G-20 20 μg  $195  M40-14G-50 50 μg  $395    Product Description     Data Sheets     Related Products     Description: Recombinant human MAPKAPK2 (46-end) was expressed in E.coli cells using an N-terminal GST tag.   Genbank Number: NM_032960   Sequence: 46-end   Expression System: E.coli   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~68 kDa Gene Aliases: (2 isoforms) Scientific Background: MAPKAPK2 (MAPKAP kinase2) is a Ser/Thr protein kinase which is regulated via direct phosphorylation by p38 MAP kinase (1). In conjunction with p38 MAP kinase, MAPKAPK2 is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 has been shown to be one of the substrates of MAPKAPK2 in vivo. References:  1. Stokoe, D. et al: The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. Biochem. J. 296: 843-849, 1993.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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