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home  products  categories  MAPKAPK3, Unactive (M41-14G) Catalog Number Pack Size Price (US) M41-14G-20 20 μg  $195  M41-14G-50 50 μg  $395    Product Description     Data Sheets     Related Products     Description: Recombinant full-length human MAPKAPK3 was expressed in E. coli cells using an N-terminal GST tag.   Genbank Number: NM_004635   Sequence: Full-length   Expression System: E. coli   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~69 kDa Gene Aliases : 3PK; MAPKAP3 Scientific Background: MAPKAPK3 is closely related to MAPKAPK2 sharing 72% nucleotide and 75% amino acid identity (1). MAPKAPK3 is activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of MAPKAPK3 as an integrative element of signaling in both mitogen and stress responses (2). References:  1. Sithanandam, G. et al: 3pK a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region. Molec. Cell. Biol. 16: 868-876, 1996. 2. Ludwig, S. et al: 3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways. Molec. Cell. Biol. 16: 6687-6697, 1996.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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