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home  products  categories  p38β, Unactive (M36-14G) Catalog Number Pack Size Price (US) M36-14G-20 20 μg  $195  M36-14G-50 50 μg  $395    Product Description     Data Sheets     Related Products     Description: Recombinant full-length human p38beta was expressed in E. coli cells using an N-terminal GST tag.   Genbank Number: NM_002751   Sequence: Full-length   Expression System: E. coli   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles Applications: Kinase Assay, Western Blot Molecular Weight: ~69 kDa Gene Aliases : MAPK11; SAPK2; p38-2; PRKM11; SAPK2B; p38b; P38b2 Scientific Background: p38-β is a member of the p38 MAP kinase family and is activated by both proinflammatory cytokines and environmental stress (1). The p38-beta is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase (2). Alternatively spliced transcript variants encoding the same protein have been observed. References:  1. Jiang, Y. et al: Characterization of the structure and function of a new mitogen-activated protein kinase (p38-beta). J. Biol. Chem. 271: 17920-17926, 1996. 2. Stein, B. et al: p38-2, a novel mitogen-activated protein kinase with distinct properties. J. Biol. Chem. 272: 19509-19517, 1997.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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