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home  products  categories  ATF1 Protein (A09-54G) Catalog Number Pack Size Price (US) A09-54G-50 50 μg  $195  A09-54G-200 200 μg  $395    15% OFF   Product Description     Data Sheets     Related Products     Description: Recombinant full-length human ATF1 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.   Genbank Number: NM_005171   Sequence: Full-length   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~63 kDa Gene Aliases: TREB36, EWS-ATF1, FUS/ATF-1 Scientific Background: ATF1 is a class of transcription factor that stimulates gene expression of several cell growth-related genes through protein kinase A-related cAMP response elements. ATF1 can physically associate with BRCA1 in vitro, in yeast, and in human cells and BRCA1 is implicated in the transcriptional activation of ATF1 target genes, some of which are involved in the transcriptional response to DNA damage (1). Mitogen- and stress-activated protein kinase 1 (MSK1) and MSK2 play a role in the stress-induced phosphorylation of ATF1 in primary embryonic fibroblasts. However, mitogen-induced phosphorylation of ATF1 is greatly reduced (2). References:  1. Houvras, Y. et al: BRCA1 physically and functionally interacts with ATF1. J Biol Chem. 2000 Nov 17;275(46):36230-7. 2. Wiggin, G R. et al: MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol. 2002 Apr;22(8):2871-81.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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