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home  products  types  CAMK2β, Active (C12-10H) Catalog Number Pack Size Price (US) C12-10H-05 5 μg  $195  C12-10H-10 10 μg  $285  C12-10H-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant full-length human CAMK2beta was expressed by baculovirus in Sf9 cells using an N-terminal His tag.   Genbank Number: NM_172081   Sequence: Full-length   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal His tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~58 kDa Gene Aliases: CAMKB, CAM2, CAMK2, MGC29528 Scientific Background: CAMK2β belongs to the serine/threonine protein kinase family and to the type II multifunctional Ca(2+)/calmodulin-dependent protein kinase subfamily. CAMK2β showed wide tissue and cell distribution, and one of CAMK2β variant predominated in adult brain (1). The ratio of CAMK2α and CAMK2β protein levels were inversely related during activity in hippocampal neurons (2). CAMK2β is a prominent kinase in the central nervous system and may function in long-term potentiation and neurotransmitter release. References:  1. Tombes, R. M. et al: Identification of novel human tumor cell-specific CaMK-II variants. Biochim. Biophys. Acta 1355: 281-292, 1997. 2. Thiagarajan, T. C. Et al: Alpha- and beta-CaMKII: inverse regulation by neuronal activity and opposing effects on synaptic strength. Neuron 36: 1103-1114, 2002.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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