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home  products  types  AURORA C, Active (A33-10G) Catalog Number Pack Size Price (US) A33-10G-05 5 μg  $195  A33-10G-10 10 μg  $285  A33-10G-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant full-length human AURORA C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.   Genbank Number: NM_003160   Sequence: Full-length   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~61 kDa Gene Aliases: AURKC, AIE2, AIK3, AurC, STK13, aurora-C Scientific Background: Aurora C is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. Aurora C has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumors (1). Aurora C overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. Aurora C is an important regulator of both genomic integrity and cell cycle progression in cancer cells and is an attractive target for anticancer drug development (2). References:  1. Steven, L. et al: Targeting Aurora-2 Kinase in Cancer. Molecular Cancer Therapeutics. 2003;2: 589-595 2. Shingo, T. et al: The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes to Cells. 2004; 9: 383-397   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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