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| Catalog Number |
Pack Size |
Price (US) |
| C58-11G-05 |
5 μg |
$195
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| C58-11G-10 |
10 μg |
$285
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| C58-11G-20 |
20 μg |
$495
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Description: Recombinant human CLK2 (137-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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Genbank Number:
NM_003993
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Sequence:
137-end
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Expression System:
Sf9 insect cells using baculovirus
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Tag:
N-terminal GST tag
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Species:
Human
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Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications: Kinase Assay, Western Blot
Molecular Weight: ~68 kDa
Gene Aliases: hCLK2, MGC61500
Scientific Background: CDC-like kinase 2 (CLK2) a family of autophosphorylating kinases termed CLK (CDC2/CDC28-like kinases) was shown to phosphorylate SR proteins and to influence alternative splicing in overexpression systems (1). Recent findings demonstrated that the CLK kinases activate PTP-1B family members, and this phosphatase may be an important cellular target for CLK action. Mutations in the clk-2 proteins affect organismal features such as development, behavior, reproduction, and aging as well as cellular features such as the cell cycle, apoptosis, the DNA replication checkpoint, and telomere length (2).
References:
1. Jiang, N. et al: Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation. J. Biol. Chem. 2003;278(24):21678-84.
2. Nayler, O. et al: The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation. J. Biol. Chem. 1998;273(51):34341-8.
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Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet. |
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Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet. |
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SAME QUALITY...
BETTER RATES
SignalChem provides all of its products in
custom pack sizes to meet your discovery needs.
more info |
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RELIABLE SERVICE...
QUALITY RESULTS
SignalChem has extensive experience in the development
and production of high quality protein 'targets'. Expertise
includes: cloning, expression and activation of signaling proteins.
more info |
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EFFICIENT PROCESS...
FAST TURNAROUND TIME
SignalChem understands that timelines are of critical
importance. We commit to providing our partners with a fully customized inclusive report within a 2-week time period.
more info |
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