Search SignalChem:   1-866-9 KINASE (54-6273)

Products Discovery Services Promotions Distribution Support Corporate Ordering

home  products  types  DAPK3, Active (D03-10G) Catalog Number Pack Size Price (US) D03-10G-05 5 μg  $195  D03-10G-10 10 μg  $285  D03-10G-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Full-length recombinant human DAPK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.   Genbank Number: NM_001348   Sequence: Full-length   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~79 kDa Gene Aliases: ZIP, ZIPK, FLJ36473 Scientific Background: DAPK3 or Death-associated protein kinase 3 (also known as ZIP) plays a role in apoptosis (1). DAPK3 is a nuclear serine/threonine-specific kinase that phosphorylates core histones H3 and H4, and myosine light chain in vitro. DAPK3 interacts with transcription and splicing factors as well as with pro-apoptotic protein Par-4 suggesting that it participates in multiple cellular processes. DAPK3 contains a leucine zipper structure at its C terminus and this region is responsible for binding to ATF4. The leucine zipper domain is necessary for the homodimerization of DAPK3 as well as for the activation of the kinase (2). References:  1. Kawai, T. et al: ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Mol. Cell Biol. 1998;18(3):1642-51. 2. Preuss, U. et al. Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase. Nucleic Acids Res. 2003; 31(3):878-85.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Bulk Orders   SAME QUALITY... BETTER RATES SignalChem provides all of its products in custom pack sizes to meet your discovery needs. more info           Custom Proteins   RELIABLE SERVICE...                 QUALITY RESULTS SignalChem has extensive experience in the development and production of high quality protein 'targets'. Expertise includes: cloning, expression and activation of signaling proteins. more info           Profiling Services   EFFICIENT PROCESS...      FAST TURNAROUND TIME SignalChem understands that timelines are of critical importance. We commit to providing our partners with a fully customized inclusive report within a 2-week time period. more info

Contact SignalChem [toll free]: 1-866-9 KINASE (54-6273) [phone]: 1-604-232-4600 [fax]: 1-604-232-4601 [email]: info@signalchem.com

Products  |   Discovery Services  |   Promotions  |   Distribution  |   Support  |   Corporate  |   Ordering Site By: Irtus Software