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| CDK7/Cyclin H1/MNAT1, Active (C36-10H) |
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| Catalog Number |
Pack Size |
Price (US) |
| C36-10H-05 |
5 μg |
$195
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| C36-10H-10 |
10 μg |
$285
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| C36-10H-20 |
20 μg |
$495
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Description: Recombinant full-length human CDK7, Cyclin H1 and MNATI were co-expressed by baculovirus in Sf9 insect cells using N-terminal His tags. |
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Genbank Number:
NM_001799
, NM_001239 , NM_002431
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Sequence:
Full-length
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Expression System:
Sf9 insect cells using baculovirus
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Tag:
N-terminal His tags
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Species:
Human
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Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications: Kinase Assay, Western Blot
Molecular Weight: ~40kDa, Cyclin H1 ~39kDa, and MNAT1 ~37kDa
Gene Aliases : CDK7: CAK1, STK1, CDKN7, p39MO15
Cyclin H1: CCNH, CAK, p34, p37
MNATI: MAT1, RNF66
Scientific Background: CDK7 gene is a member of the cyclin-dependent protein kinase family that is important regulators of cell cycle progression (1). CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH that is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle (2).
References:
1. Fisher, R. P.;A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 78: 713-724, 1994.
2. Larochelle, S. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Molec. Cell 25: 839-850, 2007.
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Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet. |
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Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet. |
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SAME QUALITY...
BETTER RATES
SignalChem provides all of its products in
custom pack sizes to meet your discovery needs.
more info |
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RELIABLE SERVICE...
QUALITY RESULTS
SignalChem has extensive experience in the development
and production of high quality protein 'targets'. Expertise
includes: cloning, expression and activation of signaling proteins.
more info |
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EFFICIENT PROCESS...
FAST TURNAROUND TIME
SignalChem understands that timelines are of critical
importance. We commit to providing our partners with a fully customized inclusive report within a 2-week time period.
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