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home  products  types  DCAMKL2, Active (D15-11G) Catalog Number Pack Size Price (US) D15-11G-05 5 μg  $195  D15-11G-10 10 μg  $285  D15-11G-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant human DCAMKL2 (1-690) was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.   Genbank Number: NM_001040261   Sequence: 1-690   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~105 kDa Gene Aliases : DCLK2; DCK2; DCDC3; DCDC3B; DKFZp761I032; MGC45428 Scientific Background: DCAMKL2 (also known as doublecortin-like kinase 2 or DCLK2) is a close homologue of doublecortin or DCX which is associated with intractable epilepsy in humans, due to a severe disorganization of the neocortex and hippocampus known as classical lissencephaly. DCX; DCLK2-null mice display frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life. DCX and DCLK2 are co-expressed in developing hippocampus, and, in their absence, there is dosage-dependent disrupted hippocampal lamination associated with a cell-autonomous simplification of pyramidal dendritic arborizations leading to reduced inhibitory synaptic tone (1). References:  1. Kerjan G. Et al: Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6766-71.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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