Search SignalChem:   1-866-9 KINASE (54-6273)

Products Discovery Services Promotions Distribution Support Corporate Ordering

home  products  types  ACK, Active (A05-11G) Catalog Number Pack Size Price (US) A05-11G-05 5 μg  $195  A05-11G-10 10 μg  $285  A05-11G-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant human ACK (110-476) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.   Genbank Number: NM_005781   Sequence: 110-476   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~66 kDa Gene Aliases: TNK2, ACK1, FLJ44758, FLJ45547, p21cdc42Hs Scientific Background: ACK is a tyrosine kinase that binds CDC42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of CDC42Hs (1). Overexpression of ACK in cancer cell lines of epithelial origin increases cellular motility and invasiveness. In a mouse model, ACK overexpression enhances the ability of a human breast cancer cell line to metastasize to the lung and increased mortality (2). Ligand stimulation of alpha-3 beta-1 integrin leads to activation of ACK which then enhances p130CAS phosphorylation and activation of RAC. References:  1.Manser, E. et al: A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature 363: 364-367, 1993. 2.van der Horst, E. H.; Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1. Proc. Nat. Acad. Sci. 102: 15901-15906, 2005.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Bulk Orders   SAME QUALITY... BETTER RATES SignalChem provides all of its products in custom pack sizes to meet your discovery needs. more info           Custom Proteins   RELIABLE SERVICE...                 QUALITY RESULTS SignalChem has extensive experience in the development and production of high quality protein 'targets'. Expertise includes: cloning, expression and activation of signaling proteins. more info           Profiling Services   EFFICIENT PROCESS...      FAST TURNAROUND TIME SignalChem understands that timelines are of critical importance. We commit to providing our partners with a fully customized inclusive report within a 2-week time period. more info

Contact SignalChem [toll free]: 1-866-9 KINASE (54-6273) [phone]: 1-604-232-4600 [fax]: 1-604-232-4601 [email]: info@signalchem.com

Products  |   Discovery Services  |   Promotions  |   Distribution  |   Support  |   Corporate  |   Ordering Site By: Irtus Software