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| DUSP22 (MKPX), Active (D22-20G) |
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Pack Size |
Price (US) |
| D22-20G-05 |
5 μg |
$195
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| D22-20G-10 |
10 μg |
$285
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| D22-20G-20 |
20 μg |
$495
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Description: Recombinant full length human DUSP22 was expressed in E.coli cells using a N-terminal GST tag. |
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Genbank Number:
NM_020185
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Sequence:
Full length
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Expression System:
E.coli
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Tag:
GST tag
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Species:
Human
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Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications: Phosphatase Assay, Western Blot
Molecular Weight: ~43 kDa
Gene Aliases: VHX, JKAP, JSP1, MKPX
Scientific Background: Dual specificity phosphatases (DUSP) family, which can dephosphorylate both phosphoserine/threonine and phosphotyrosine residues, comprise of two subgroups: "typical" DUSP (include 11 MKPs that dephosphorylate the mitogen-activated protein kinases Erk, Jnk, and p38 at their dually phosphorylated TXY activation loop motif) and "atypical" DUSP (include 8 enzymes that lack specific MAP kinase-targeting motifs and tend to be much smaller proteins, which are less than 250 amino acid residues) (1). DUSP22, also called JKAP, JSP1 and MKPX plays a role in various inflammatory and proliferative disorders associated with dysfunctional Jnk signaling (2).
References:
1. Andres, A. et al: VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. J Biol Chem. 2004 Jul 30; 279(31): 32586-91. Epub 2004 May 11.
2. Shen, Y. et al: Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24): 13613-8.
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Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet. |
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Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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SAME QUALITY...
BETTER RATES
SignalChem provides all of its products in
custom pack sizes to meet your discovery needs.
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RELIABLE SERVICE...
QUALITY RESULTS
SignalChem has extensive experience in the development
and production of high quality protein 'targets'. Expertise
includes: cloning, expression and activation of signaling proteins.
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EFFICIENT PROCESS...
FAST TURNAROUND TIME
SignalChem understands that timelines are of critical
importance. We commit to providing our partners with a fully customized inclusive report within a 2-week time period.
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