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home  products  types  BRK, Active (P94-10G) Catalog Number Pack Size Price (US) P94-10G-05 5 μg  $195  P94-10G-10 10 μg  $285  P94-10G-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant full-length human BRK was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.   Genbank Number: NM_005975   Sequence: Full-length   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~80 kDa Gene Aliases : PTK6; FLJ42088 Scientific Background: BRK is a member of the non-receptor tyrosine kinases (PTKs) that contains an amino terminal SH3 and SH2 domain as well as the catalytic domain (1). BRK expression is low or undetectable in normal mammary tissue and benign lesions. However, approximately two-thirds of breast tumors express appreciable levels, and 27% of tumors over express BRK by fivefold or more (2). References:  1. Mitchell, PJ. et al: Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours. Oncogene. 1994 Aug;9(8):2383-90. 2. Mitchell, PJ. et al: Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brk. Oncogene. 1997 Sep 18;15(12):1497-502.Erratum in: Oncogene 1998 Jul 9;17(1):129.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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