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home  products  types  CSK, Active (C63-10U) Catalog Number Pack Size Price (US) C63-10U-05 5 μg  $195  C63-10U-10 10 μg  $285  C63-10U-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant full-length tag-free human CSK was expressed by baculovirus in Sf9 insect cells.   Genbank Number: NM_004383   Sequence: Full-length   Expression System: Sf9 insect cells using baculovirus   Tag: Tag-free   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~52 kDa Gene Aliases : MGC117393 Scientific Background: CSK is a cytoplasmic tyrosine kinase that has been shown to downregulate the tyrosine kinase activity of the c-src through tyrosine phosphorylation of the c-src carboxy terminus (1). A yeast 2-hybrid system has been used to identify proteins associated with CSK. The Src homology-3 (SH3) domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells (2). This association is highly specific and it is speculated that PEP may be an effector and/or regulator of CSK in T cells and other hemopoietic cells. References:  1. Partanen, J. et al: Cyl encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416-src). Oncogene 6: 2013-2018, 1991. 2. Cloutier, J.-F. et al: Association of inhibitory tyrosine protein kinase p50(csk) with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. EMBO J. 15: 4909-4918, 1996.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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