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home  products  types  CHK2, Active (C48-10G) Catalog Number Pack Size Price (US) C48-10G-05 5 μg  $195  C48-10G-10 10 μg  $285  C48-10G-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant full-length human CHK2 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.   Genbank Number: NM_007194   Sequence: Full-length   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~88 kDa Gene Aliases : RP11-436C9.1, CDS1, CHEK2, HuCds1, LFS2, PP1425, RAD53 Scientific Background: CHK2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage; the response to DNA damage occurs in an ataxia telangiectasia mutated (ATM)-dependent manner (1). Expression of wild-type Chk2 leads to increased p53 stabilization after DNA damage, whereas expression of a dominant-negative Chk2 mutant abrogated both phosphorylation of p53 on Ser-20 and p53 stabilization (2). References:  1. Matsuoka, S. et al: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science. 1998 Dec 4;282(5395):1893-7. 2. Chehab NH. et al: Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev. 2000 Feb 1;14(3):278-88.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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