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home  products  types  CK2α1, Active (C70-10G) Catalog Number Pack Size Price (US) C70-10G-05 5 μg  $195  C70-10G-10 10 μg  $285  C70-10G-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant full-length human CK2alpha1 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.   Genbank Number: NM_001895   Sequence: Full-length   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~70 kDa Gene Aliases : CKII; CK2A1; CKIIα Scientific Background: CK2α is a serine-threonine protein kinase whose targets include many critical regulators of cellular growth. It is highly expressed in a lymphopro-liferative disease of cattle and in many human cancers. Overexpression of the CK2 catalytic subunit in lymphocytes of transgenic mice leads to T cell lymphoma (1). The highest CK2α1 activity is found in mouse testicles and brain, followed by spleen, liver, lung, kidney and heart (2). References:  1. Rifkin, IR. et al: Acceleration of lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha. J Immunol. 1998 Nov 15;161(10):5164-70. 2. Guerra B. et al: Protein kinase CK2: evidence for a protein kinase CK2beta subunit fraction, devoid of the catalytic CK2alpha subunit, in mouse brain and testicles. FEBS Lett. 1999 Dec 3;462(3):353-7.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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