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CAMKK2, Active (C18-10G)

Catalog Number	Pack Size	Price (US)
C18-10G-05	5 μg	$195
C18-10G-10	10 μg	$285
C18-10G-20	20 μg	$495


	Product Description


	Data Sheets


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Description: Recombinant full-length human CAMKK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Genbank Number: NM_172226

Sequence: Full-length

Expression System: Sf9 insect cells using baculovirus

Tag: N-terminal GST tag

Species: Human

Storage and Stability: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~88 kDa

Gene Aliases : CAMKK; CAMKKB; KIAA0787; MGC15254

Scientific Background: CAMKK2 (CAMKKβ) is a member of the CAMKK family. It is broadly distributed in tissues with highest levels in brain, thymus, spleen, and testis (1). CaMKK2 undergoes intramolecular autophosphorylation, is regulated by Ca2+/calmodulin and phosphorylates CaMKI and CaMKIV on Thr177 and Thr200, respectively. CaMKK2 activates both CaMKI and CaMKIV when coexpressed in Jurkat T cells. CaMKK2 also phosphorylates and regulates the activity of AMPK, which is an important regulator of cellular metabolism in response to metabolic stress (2).

References:
1. Anderson, K.A. et al: Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.

2. Hurley, R.L. et al: The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem. 2005 Aug 12;280(32):29060-6.

Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.


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