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home  products  types  CAMK2α, Active (C11-10G) Catalog Number Pack Size Price (US) C11-10G-05 5 μg  $195  C11-10G-10 10 μg  $285  C11-10G-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant full-length human CAMK2alpha was expressed in Sf9 cells using an N-terminal GST tag.   Genbank Number: NM_171825   Sequence: Full-length   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal GST tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~74 kDa Gene Aliases: CAMKA; KIAA0968 Scientific Background: CAMK2α is a ser/thr protein kinase that is a member of the Ca2+/calmodulin-dependent protein kinase family. CAMK2α is abundant in the brain as a major constituent of the postsynaptic density and is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its Ca2+/calmodulin-dependent activity, CAMK2α can undergo autophosphorylation, resulting in Ca2+/calmodulin-independent activity. The protein level of CAMK2α fluctuates during neuronal activity in cultured rat pup hippocampal neurons. The levels of CAMK2α increased with heightened neuronal activity (2). References:  1. Silva, A J. et al: Impaired spatial learning in alpha-calcium calmodulin kinase II mutant mice. Science 257: 206-211, 1992. 2. Thiagarajan, T C. et al: Alpha- and beta-CaMKII: inverse regulation by neuronal activity and opposing effects on synaptic strength. Neuron 36: 1103-1114, 2002.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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