Search SignalChem:   1-866-9 KINASE (54-6273)

Products Discovery Services Promotions Distribution Support Corporate Ordering

home  products  types  ABL2, Active (A04-11H) Catalog Number Pack Size Price (US) A04-11H-05 5 μg  $195  A04-11H-10 10 μg  $285  A04-11H-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant human ABL2 (38-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.   Genbank Number: NM_005158   Sequence: 38-end   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal His tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~132 kDa Gene Aliases: ARG; ABLL Scientific Background: ABL2 (or ARG) is a nonreceptor cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of ABL1 and ABL2 includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is involved in translocation with the ETV6 gene in human leukemia and has an altered expression in several human carcinomas (1). Two isoforms of ABL2 with different N-termini (1A and 1B) have been identified. The C-terminal domain of ABL2 contains two F-actin-binding sequences that perform a number of actions related to cell morphology and motility by interacting with actin filaments (2). References:  1. Barila, D. et al : An intramolecular SH3-domain interaction regulates c-Abl activity. Nature Genet. 18: 280-282, 1998. 2. Griesinger, F. et al: Identification of an ETV6-ABL2 fusion transcript in combination with an ETV6 point mutation in a T-cell acute lymphoblastic leukaemia cell line. Br J Haematol. 2002 Nov;119(2):454-8.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Bulk Orders   SAME QUALITY... BETTER RATES SignalChem provides all of its products in custom pack sizes to meet your discovery needs. more info           Custom Proteins   RELIABLE SERVICE...                 QUALITY RESULTS SignalChem has extensive experience in the development and production of high quality protein 'targets'. Expertise includes: cloning, expression and activation of signaling proteins. more info           Profiling Services   EFFICIENT PROCESS...      FAST TURNAROUND TIME SignalChem understands that timelines are of critical importance. We commit to providing our partners with a fully customized inclusive report within a 2-week time period. more info

Contact SignalChem [toll free]: 1-866-9 KINASE (54-6273) [phone]: 1-604-232-4600 [fax]: 1-604-232-4601 [email]: info@signalchem.com

Products  |   Discovery Services  |   Promotions  |   Distribution  |   Support  |   Corporate  |   Ordering Site By: Irtus Software