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home  products  types  BTK, Active (B10-10H) Catalog Number Pack Size Price (US) B10-10H-05 5 μg  $195  B10-10H-10 10 μg  $285  B10-10H-20 20 μg  $495    Product Description     Data Sheets     Related Products     Description: Recombinant full-length human BTK was expressed by baculovirus in Sf9 insect cells using a N-terminal His tag.   Genbank Number: NM_000061   Sequence: Full-length   Expression System: Sf9 insect cells using baculovirus   Tag: N-terminal His tag   Species: Human Storage and Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Applications: Kinase Assay, Western Blot Molecular Weight: ~78 kDa Gene Aliases: AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK Scientific Background: BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors (1). Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments (2). References:  1. Cheng, G. et al: Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. Proc. Nat. Acad. Sci. 91: 8152-8155, 1994. 2. Vassilev, A O. et al: Therapeutic potential of inhibiting Bruton's tyrosine kinase, (BTK). Curr Pharm Des. 2004;10(15):1757-66.   Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.   Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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