Description: Rabbit Polyclonal Antibody

Specificity: Recognizes the p38β protein

Cited Applications: WB

Cross Reactivity: Western blot human p38β

p38β from other species may also be detectable.

Host: Rabbit

Immunogen: C-terminal peptide of p38β conjugated to ovalbumin

Formulation: TBS at pH 7.2, 50% glycerol

Purification: Affinity chromatography

Stability: Store at 4°C (add 0.1% NaN₃) for several months, and at -20°C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.

Scientific Background: p38β is a member of the p38 MAP kinase family and is activated by both proinflammatory cytokines and environmental stress (1). The p38β is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase (2). Alternatively spliced transcript variants encoding the same protein have been observed.

References: 1. Jiang, Y. et al: Characterization of the structure and function of a new mitogen-activated protein kinase (p38-beta). J. Biol. Chem. 271: 17920-17926, 1996.

2. Stein, B. et al: p38-2, a novel mitogen-activated protein kinase with distinct properties. J. Biol. Chem. 272: 19509-19517, 1997.

		Sample Western Blot:  Representative western blot (1:1000) using 20ng of p38α, p38β, p38γ, and p38δ recombinant protein.

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