Active Arginine Deiminases


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SignalChem's Active Arginine Deiminases

Peptidylarginine deiminases (PADs) are enzymes that catalyze the hydrolytic conversion of arginines into citrullines (citrullination). Humans have five PADs (1-4 and 6) and these are widely expressed in the body.


Citrullination is required for a wide range of biological functions including epigenetic modifications. PAD4 is responsible for promoting chromatin decondensation via the citrullination of histone tails. Over-expression or over-activity of PAD4 can lead to the aberrant production of proteins, which include cytokines. Excess cytokine levels are implicated in neurodegenerative diseases and cancers. PADs have been studied as a promising drug targets for the treatment of arginine-auxotrophic tumors such as hepatocellular carcinomas (HCCs) and melanomas.


SignalChem offers all five mammalian PADs and a PAD Cocktail to facilitate studies on this interesting class of enzymes.


Active Arginine Deiminases Product Listing Found: Total 1 Products Matching Active Arginine Deiminases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
PAD Cocktail, Active P312-37C Full Length
Active Arginine Deiminases Product Listing Found: Total 1 Products Matching Active Arginine Deiminases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Arginine Deiminases Product Listing Found: Total 1 Products Matching Active Arginine Deiminases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Arginine Deiminases Product Listing Found: Total 1 Products Matching Active Arginine Deiminases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Arginine Deiminases Product Listing Found: Total 1 Products Matching Active Arginine Deiminases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Arginine Deiminases Product Listing Found: Total 1 Products Matching Active Arginine Deiminases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Arginine Deiminases Product Listing Found: Total 1 Products Matching Active Arginine Deiminases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
PAD Cocktail, Active P312-37C Full Length
Active Arginine Deiminases Product Listing Found: Total 1 Products Matching Active Arginine Deiminases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Arginine Deiminases Product Listing Found: Total 1 Products Matching Active Arginine Deiminases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Arginine Deiminases Product Listing Found: Total 1 Products Matching Active Arginine Deiminases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Arginine Deiminases Product Listing Found: Total 1 Products Matching Active Arginine Deiminases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Arginine Deiminases Product Listing Found: Total 1 Products Matching Active Arginine Deiminases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number


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Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active GTPases/ATPases Active GTPases/ATPases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinase Mutants Active Kinase Mutants
Enzymes Active Kinases Active Kinases
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Biochemical Compounds Phosphatase Inhibitors Phosphatase Inhibitors
Biochemical Compounds siRNA Controls siRNA Controls
Biochemical Compounds siRNA Sets siRNA Sets
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferases Acetyl/Methyltransferases
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
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Cell Cycle Cell Cycle
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p38 Pathway p38 Pathway
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WNT Signaling WNT Signaling




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