HDAC1 Active Enzymes Active Histone Deacetylases


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HDAC1, Active (H83-30G)
Catalog Number Pack Size Price (USD)  
HDAC1, Active H83-30G-05 5 ug $205   HDAC1, Active Add to Cart
HDAC1, Active H83-30G-10 10 ug $295   HDAC1, Active Add to Cart
HDAC1, Active H83-30G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Full-length recombinant human HDAC1 was expressed by baculovirus in Sf9 insect cells using a C-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_004964
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: HDAC Assay, Western Blot

Molecular Weight: ~88 kDa

Gene Aliases : HD1, RPD3, GON-10, RPD3L1, DKFZp686H12203

Scientific Background: HDAC1 or Histone deacetylase 1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex which plays a key role in the regulation of eukaryotic gene expression (1). HDAC1 interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis. HDAC1 is an essential element of the co-activation system for IFN-induced gene regulation and antiviral responses (2).

References: 
1. Bauer, W. R. et.al : Nucleosome structural changes due to acetylation. J. Molec. Biol. 236: 685-690, 1994.

2. Nusinzon, I. et.al : Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc. Nat. Acad. Sci. 100: 14742-14747, 2003.



  Specific Activity:  Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




HDAC1, Active Research Areas

The HDAC1, Active product can be utilized in the following research areas, but not limited to:

Cancer, Cell Cycle, Inflammation



HDAC1, Active Related Products Found: Total 22 Related Products
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Antibodies Anti-Acetylated Lysine, HRP Conjugated L95-66DR WB, ELISA, IP, IHC, IF View Anti-Acetylated Lysine, HRP Conjugated
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Signaling Reagents Acetylated Histone H3 Peptide I H12-358 Acetylation/Methylation Assays View Acetylated Histone H3 Peptide I
Signaling Reagents Acetylated Histone H4 Peptide I H13-358 Acetylation/Methylation Assays View Acetylated Histone H4 Peptide I


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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