Description: Full-length recombinant human HDAC2 was expressed by baculovirus in Sf9 insect cells using a C-terminal GST tag.

Storage, Stability, and Shipping: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: HDAC Assay, Western Blot

Molecular Weight: ~92 kDa

Gene Aliases : RPD3; YAF1

Scientific Background: HDAC2 or Histone deacetylase 2 belongs to the histone deacetylase family that acts via the formation of large multiprotein complexes, and is responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). HDAC2 forms transcriptional repressor complexes by associating with many different proteins and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDAC2 functions in modulating synaptic plasticity and long-lasting changes of neural circuits, which in turn negatively regulates learning and memory (1). HDAC1 and HDAC2 are functionally redundant in cardiac growth and development and they maintain cardiomyocyte identity and function (2).

References: 
1. Guan, J.S.. et.al: HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459: 55-60, 2009.

2. Montgomery, R. L. et.al: Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev. 21: 1790-1802, 2007.

		Specific Activity:  Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.

		Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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