HDAC3 Active Enzymes Active Histone Deacetylases


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HDAC3, Active (H85-30G)

Catalog Number Pack Size Price (USD)  
HDAC3, Active H85-30G-05 5 ug $205   HDAC3, Active Add to Cart
HDAC3, Active H85-30G-10 10 ug $295   HDAC3, Active Add to Cart
HDAC3, Active H85-30G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Full-length recombinant human HDAC3 was expressed by baculovirus in Sf9 insect cells using a C-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full Length
Genbank Number: NM_003883
   

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: HDAC Assay, Western Blot

Molecular Weight: ~83 kDa

Gene Aliases: HD3; RPD3; RPD3-2

Scientific Background: HDAC3 or Histone deacetylase 3 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex that represses transcription when tethered to a promoter. HDAC3 may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. HDAC3 can also down-regulate p53 function and thus modulate cell growth and apoptosis. Catalytic domain of HDAC4 can interact with HDAC3 via the transcriptional corepressor NCOR2 (1). RELA is a nonhistone substrate of HDAC3 and IKBA-dependent nuclear export of the HDAC3-deacetylated RELA replenishes the depleted cytoplasmic pool of latent NFKB-IKBA complexes (2).

References
1. Chen, L. et. al: Duration of nuclear NF-kappa-B action regulated by reversible acetylation. Science 293: 1653-1657, 2001.

2. Fischle, W. et al: Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Molec. Cell 9: 45-57, 2002.



  Specific Activity:  Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




HDAC3, Active Research Areas

The HDAC3, Active product can be utilized in the following research areas, but not limited to:

Cancer, Cell Cycle, Inflammation



HDAC3, Active Related Products Found: Total 21 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes HDAC1, Active H83-30G HDAC Assay, Western Blot View HDAC1, Active
Enzymes HDAC2, Active H84-30G HDAC Assay, Western Blot View HDAC2, Active
Enzymes HDAC8, Active H90-30H HDAC Assay, Western Blot View HDAC8, Active
Enzymes HDAC7, Active H89-31G HDAC Assay, Western Blot View HDAC7, Active
Enzymes HDAC9, Active H91-31G HDAC Assay, Western Blot View HDAC9, Active
Enzymes HDAC10, Active H92-31G HDAC Assay, Western Blot View HDAC10, Active
Antibodies Anti-HDAC1 H83-63R WB View Anti-HDAC1
Antibodies Anti-HDAC2 H84-63R WB View Anti-HDAC2
Antibodies Anti-HDAC8 H90-63R WB View Anti-HDAC8
Antibodies Anti-HDAC4 H86-63R WB View Anti-HDAC4
Antibodies Anti-HDAC9 H91-63R WB View Anti-HDAC9
Enzymes HDAC5, Active H87-31G HDAC Assay, Western Blot View HDAC5, Active
Enzymes HDAC11, Active H93-30G HDAC Assay, Western Blot View HDAC11, Active
Enzymes HDAC4, Active H86-31G HDAC Assay, Western Blot View HDAC4, Active
Enzymes HDAC6, Active H88-30G HDAC Assay, Western Blot View HDAC6, Active
Antibodies Anti-Acetylated Lysine, Biotin Conjugated L95-66BR WB, ELISA, IP, IHC, IF View Anti-Acetylated Lysine, Biotin Conjugated
Antibodies Anti-Acetylated Lysine, FITC Conjugated L95-66CR For direct immunofluorescence assay View Anti-Acetylated Lysine, FITC Conjugated
Antibodies Anti-Acetylated Lysine, HRP Conjugated L95-66DR WB, ELISA, IP, IHC, IF View Anti-Acetylated Lysine, HRP Conjugated
Antibodies Anti-Acetylated Lysine L95-66R WB, ELISA, IP, IHC, IF View Anti-Acetylated Lysine
Signaling Reagents Acetylated Histone H3 Peptide I H12-358 Acetylation/Methylation Assays View Acetylated Histone H3 Peptide I
Signaling Reagents Acetylated Histone H4 Peptide I H13-358 Acetylation/Methylation Assays View Acetylated Histone H4 Peptide I


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinase Mutants Active Kinase Mutants
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferases Active Methyltransferases
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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