SIRT1 Active Enzymes Active Histone Deacetylases


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SIRT1, Active (S35-31H)
Catalog Number Pack Size Price (USD)  
SIRT1, Active S35-31H-05 5 ug $235   SIRT1, Active Add to Cart
SIRT1, Active S35-31H-10 10 ug $345   SIRT1, Active Add to Cart
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Product Data Sheet(s)




Description: Recombinant human SIRT1 (193-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Tag: His tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 193-end
Genbank Number: NM_012238
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: SIRT Assay

Molecular Weight: ~84 kDa

Gene Aliases: SIR2L1

Scientific Background: SIRT1 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT1 being a member of class I. SIRT1 is a stress-response and chromatin-silencing factor (1). It is an NAD(+)-dependent histone deacetylase involved in various nuclear events such as transcription, DNA replication, and DNA repair. SIRT1 protein binds and deacetylates the p53 protein (2). Expression of wild type SIRT1 in human cells reduces the transcriptional activity of p53 indicating that SIRT1 is involved in the regulation of p53 function via deacetylation.

References: 
1. Tanny, J. C. et al: An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell 99: 735-745, 1999.

2. Vaziri, H. et al: hSIR2-SIRT1 functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159, 2001.



  Specific Activity:  Sample SIRT Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




SIRT1, Active Research Areas

The SIRT1, Active product can be utilized in the following research areas, but not limited to:

Cancer, Cell Cycle, Inflammation



SIRT1, Active Related Products Found: Total 14 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Signaling Proteins SIRT1 Protein S35-31EG Western Blot View SIRT1 Protein
Signaling Proteins SIRT2 Protein S36-30EG Western Blot View SIRT2 Protein
Enzymes SIRT2, Active S36-30H SIRT Assay View SIRT2, Active
Signaling Proteins SIRT3 Protein S37-30EG Western Blot View SIRT3 Protein
Signaling Proteins SIRT4 Protein S38-30EG Western Blot View SIRT4 Protein
Signaling Proteins SIRT5 Protein S39-30EG Western Blot View SIRT5 Protein
Enzymes SIRT5, Active S39-30H SIRT Assay View SIRT5, Active
Signaling Proteins SIRT6 Protein S40-30EG Western Blot View SIRT6 Protein
Enzymes SIRT6, Active S40-31H SIRT Assay View SIRT6, Active
Enzymes SIRT7, Active S41-30H SIRT Assay View SIRT7, Active
Enzymes WNK1, Active W02-11G Kinase Assay, Western Blot View WNK1, Active
Enzymes SIRT3, Active S37-38G SIRT Assay View SIRT3, Active
Signaling Reagents Acetylated Histone H3 Peptide I H12-358 Acetylation/Methylation Assays View Acetylated Histone H3 Peptide I
Signaling Reagents Acetylated Histone H4 Peptide I H13-358 Acetylation/Methylation Assays View Acetylated Histone H4 Peptide I


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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