Active Histone Deacetylases


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SignalChem's Active Histone Deacetylases

Histone deacetylases or HDACs are a class of enzymes that belongs to the histone deacetylase/acuc/apha family (there are at least 11 family members) and catalyze the deacetylation of lysine residues in different proteins. HDACs are involved in a variety of signaling pathways (such as notch signaling pathway), cell cycle progression and play an important role in gene expression and transcriptional regulation.


The HDACs are found in both the nuclear and cytoplasmic compartment of the cell and have many diverse downstream target substrates. Members of the class I HDAC family can deacetylase the histone N-terminal tail and represses transcription in large multiprotein complexes with transcriptional co-repressors. Furthermore, HDACs can interact with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDACs can deacetylate p53 and modulates its effect on cell growth and apoptosis.


Histone acetylation has been shown to be important in cognitive aging, neurodegeneration, and neuropsychiatric diseases and inhibitors of HDACs exhibit neuroprotective and neuroregenerative properties in animal models of various brain diseases. Furthermore, HDACs have been shown to be commonly associated with many types of cancers and are thought to be involved in cancer development. Therefore, targeting of HDACs seems to be a promising therapeutic strategy against cancers such as colon, lung and cervical as well as chronic myeloid leukemia.


SignalChem offers a diverse and comprehensive range of active HDACs and these can be used to perform deacetylase reaction towards a variety of substrate proteins and peptides.


Active Histone Deacetylases Product Listing Found: Total 19 Products Matching Active Histone Deacetylases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
HDAC1, Active H83-30G Human GST tag Sf9 insect cells Full Length NM_004964
HDAC10, Active H92-31G Human GST tag Sf9 insect cells 1-482 NM_032019
HDAC11, Active H93-30G Human GST tag Sf9 insect cells Full Length NM_024827
HDAC2, Active H84-30G Human GST tag Sf9 insect cells Full Length NM_001527
HDAC3, Active H85-30G Human GST tag Sf9 insect cells Full Length NM_003883
HDAC3/NCOR2, Active H85-38G Human GST tags Sf9 insect cells HDAC3 (full-length)/NCOR2 (237-489) NM_003883
HDAC4, Active H86-31G Human GST tag Sf9 insect cells 612-end NM_006037
HDAC5, Active H87-31G Mouse GST tag Sf9 insect cells 617-end BC060609
HDAC6, Active H88-30G Human GST tag Sf9 insect cells Full Length BC069243
HDAC7, Active H89-31G Human GST tag Sf9 insect cells 501-end NM_015401
HDAC8, Active H90-30H Human His tag Sf9 insect cells Full Length BC050433
HDAC8, Active H90-30G Human GST tag Sf9 insect cells Full length BC050433
HDAC9, Active H91-31G Human GST tag Sf9 insect cells 548-end NM_058176
SIRT1, Active S35-31H Human His tag Sf9 insect cells 193-end NM_012238
SIRT2, Active S36-30H Human His tag Sf9 insect cells Full Length NM_030593
SIRT3, Active S37-38G Human GST tag Sf9 insect cells 47-end NM_012239
SIRT5, Active S39-30H Human His tag Sf9 insect cells Full Length NM_012241
SIRT6, Active S40-31H Human His tag Sf9 insect cells 23-end NM_016539
SIRT7, Active S41-30H Human His tag Sf9 insect cells Full Length NM_016538
Active Histone Deacetylases Product Listing Found: Total 19 Products Matching Active Histone Deacetylases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Histone Deacetylases Product Listing Found: Total 19 Products Matching Active Histone Deacetylases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Histone Deacetylases Product Listing Found: Total 19 Products Matching Active Histone Deacetylases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
HDAC1, Active H83-30G Human GST tag Sf9 insect cells Full Length NM_004964
HDAC10, Active H92-31G Human GST tag Sf9 insect cells 1-482 NM_032019
HDAC11, Active H93-30G Human GST tag Sf9 insect cells Full Length NM_024827
HDAC2, Active H84-30G Human GST tag Sf9 insect cells Full Length NM_001527
HDAC3, Active H85-30G Human GST tag Sf9 insect cells Full Length NM_003883
HDAC3/NCOR2, Active H85-38G Human GST tags Sf9 insect cells HDAC3 (full-length)/NCOR2 (237-489) NM_003883
HDAC4, Active H86-31G Human GST tag Sf9 insect cells 612-end NM_006037
HDAC5, Active H87-31G Mouse GST tag Sf9 insect cells 617-end BC060609
HDAC6, Active H88-30G Human GST tag Sf9 insect cells Full Length BC069243
HDAC7, Active H89-31G Human GST tag Sf9 insect cells 501-end NM_015401
HDAC8, Active H90-30H Human His tag Sf9 insect cells Full Length BC050433
HDAC8, Active H90-30G Human GST tag Sf9 insect cells Full length BC050433
HDAC9, Active H91-31G Human GST tag Sf9 insect cells 548-end NM_058176
Active Histone Deacetylases Product Listing Found: Total 19 Products Matching Active Histone Deacetylases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Histone Deacetylases Product Listing Found: Total 19 Products Matching Active Histone Deacetylases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Histone Deacetylases Product Listing Found: Total 19 Products Matching Active Histone Deacetylases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
SIRT1, Active S35-31H Human His tag Sf9 insect cells 193-end NM_012238
SIRT2, Active S36-30H Human His tag Sf9 insect cells Full Length NM_030593
SIRT3, Active S37-38G Human GST tag Sf9 insect cells 47-end NM_012239
SIRT5, Active S39-30H Human His tag Sf9 insect cells Full Length NM_012241
SIRT6, Active S40-31H Human His tag Sf9 insect cells 23-end NM_016539
SIRT7, Active S41-30H Human His tag Sf9 insect cells Full Length NM_016538
Active Histone Deacetylases Product Listing Found: Total 19 Products Matching Active Histone Deacetylases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Histone Deacetylases Product Listing Found: Total 19 Products Matching Active Histone Deacetylases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Histone Deacetylases Product Listing Found: Total 19 Products Matching Active Histone Deacetylases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Histone Deacetylases Product Listing Found: Total 19 Products Matching Active Histone Deacetylases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Histone Deacetylases Product Listing Found: Total 19 Products Matching Active Histone Deacetylases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number


Sirtuins are class III histone deacetylases that have a NAD+ deacetylase and/or ADP-ribosyl transferase activity. The 7 members of sirtuins (SIRT1 through SIRT7) post-translationally modify a number of cellular proteins, affecting cell cycle regulation, cell differentiation, genomic stability, tumorigenesis, oxidative stress response, energy metabolism and other cellular processes. Although there is no direct evidence for the role of sirtuins in extending lifespan in mammals, various mouse models show that small molecules targeting SIRT proteins may treat age-associated diseases including diabetes, cancer and cardiac dysfunction.
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