ABL1 (G250E) Active Enzymes Active Kinases


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ABL1 (G250E), Active (A03-12CG)
Catalog Number Pack Size Price (USD)  
ABL1 (G250E), Active A03-12CG-05 5 ug $205   ABL1 (G250E), Active Add to Cart
ABL1 (G250E), Active A03-12CG-10 10 ug $295   ABL1 (G250E), Active Add to Cart
ABL1 (G250E), Active A03-12CG-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant human ABL1 (G250E) (27-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 27-end
Genbank Number: NM_005157
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~160 kDa

Gene Aliases: ABL; JTK7; p150; c-ABL; v-abl; bcr/abl

Scientific Background: ABL1protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of ABL protein is negatively regulated by its SH3 domain and deletion of the SH3 domain turns ABL1 into an oncogene (1). Translocation and head-to-tail fusion of the BCR and ABL1 genes is present in many cases of chronic myelogeneous leukemia (2). The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDK1-mediated phosphorylation, suggesting a cell cycle function for ABL1.

References: 
1. Barila, D. et al : An intramolecular SH3-domain interaction regulates c-Abl activity. Nature Genet. 18: 280-282, 1998.

2. Goldman, J M. et al : Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia. New Eng. J. Med. 344: 1084-1086, 2001.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




ABL1 (G250E), Active Research Areas

The ABL1 (G250E), Active product can be utilized in the following research areas, but not limited to:

Cancer, Cell Cycle, Cytoplasmic Tyrosine Kinases, Inflammation, Invasion/Metastasis, Neurobiology



ABL1 (G250E), Active Related Products Found: Total 4 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Signaling Reagents Kinase Dilution Buffer IV K24-09 Kinase Assay View Kinase Dilution Buffer IV
Signaling Reagents Kinase Assay Buffer II K02-09 Kinase Assay View Kinase Assay Buffer II
Signaling Reagents ATP Stock Solution A50-09 Kinase Assay View ATP Stock Solution
Signaling Reagents Abltide A02-58 Kinase Assay View Abltide


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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