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ACK, Active (A05-11G)
Catalog Number Pack Size Price (USD)  
ACK, Active A05-11G-05 5 ug $205   ACK, Active Add to Cart
ACK, Active A05-11G-10 10 ug $295   ACK, Active Add to Cart
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Product Data Sheet(s)




Description: Recombinant human ACK (110-476) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 110-476
Genbank Number: NM_005781
   

References: 
1.Manser, E. et al: A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature 363: 364-367, 1993.

2.van der Horst, E. H.; Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1. Proc. Nat. Acad. Sci. 102: 15901-15906, 2005.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~66 kDa

Gene Aliases: TNK2, ACK1, FLJ44758, FLJ45547, p21cdc42Hs

Scientific Background: ACK is a tyrosine kinase that binds CDC42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of CDC42Hs (1). Overexpression of ACK in cancer cell lines of epithelial origin increases cellular motility and invasiveness. In a mouse model, ACK overexpression enhances the ability of a human breast cancer cell line to metastasize to the lung and increased mortality (2). Ligand stimulation of alpha-3 beta-1 integrin leads to activation of ACK which then enhances p130CAS phosphorylation and activation of RAC.

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




ACK, Active Research Areas

The ACK, Active product can be utilized in the following research areas, but not limited to:

Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Receptor Tyrosine Kinases



ACK, Active Related Products Found: Total 1 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Signaling Reagents Poly (4:1 Glu, Tyr) Peptide P61-58 Kinase Assay View Poly (4:1 Glu, Tyr) Peptide


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
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Enzymes Active Kinases Active Kinases
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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