1.Manser, E. et al: A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature 363: 364-367, 1993.
2.van der Horst, E. H.; Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1. Proc. Nat. Acad. Sci. 102: 15901-15906, 2005.
: Kinase Assay, Western Blot
: ~66 kDa
: TNK2, ACK1, FLJ44758, FLJ45547, p21cdc42Hs
: ACK is a tyrosine kinase that binds CDC42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of CDC42Hs (1). Overexpression of ACK in cancer cell lines of epithelial origin increases cellular motility and invasiveness. In a mouse model, ACK overexpression enhances the ability of a human breast cancer cell line to metastasize to the lung and increased mortality (2). Ligand stimulation of alpha-3 beta-1 integrin leads to activation of ACK which then enhances p130CAS phosphorylation and activation of RAC.
Storage, Stability, and Shipping
: Store product at –70o
C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
||Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
||Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
The ACK, Active product can be utilized in the following research areas, but not limited to:
Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Receptor Tyrosine Kinases