ALK3 (BMPR1A) Active Enzymes Active Kinases


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ALK3 (BMPR1A), Active (B04-11G)
Catalog Number Pack Size Price (USD)  
ALK3 (BMPR1A), Active B04-11G-05 5 ug $205   ALK3 (BMPR1A), Active Add to Cart
ALK3 (BMPR1A), Active B04-11G-10 10 ug $295   ALK3 (BMPR1A), Active Add to Cart
ALK3 (BMPR1A), Active B04-11G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant human ALK3 (BMPR1A) (187-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 187-end
Genbank Number: NM_004329
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~66 kDa

Gene Aliases: ALK3; BMPR1A; 10q23del; ACVRLK3; CD292; SKR5

Scientific Background: BMPR1A (also known as bone morphogenetic protein receptor 1A) is a member of the transmembrane serine/threonine kinase family that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A act as a minor susceptibility gene for PTEN-mutation-negative Cowden syndrome. BMPR1A regulates the PTEN protein levels by decreasing PTEN's association with the degradative pathway (1). BMPR1A trafficking plays a significant role in FOP pathogenesis and is also involved in human T-cell differentiation (2).

References: 
1. Waite, K. A. et.al: BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels. Hum. Molec. Genet. 12: 679-684, 2003.

2. Cejalvo, T. et.al: Bone morphogenetic protein-2/4 signalling pathway components are expressed in the human thymus and inhibit early T-cell development. Immunology 121: 94-104, 2007.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




ALK3 (BMPR1A), Active Research Areas

The ALK3 (BMPR1A), Active product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Angiogenesis, Cancer, Cardiovascular Disease, JAK/STAT Pathway, Neurobiology, Ser/Thr Kinases



ALK3 (BMPR1A), Active Related Products Found: Total 5 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes ALK1, Active A09-11G Kinase Assay, Western Blot View ALK1, Active
Enzymes ALK2, Active A06-11G Kinase Assay, Western Blot View ALK2, Active
Enzymes ALK4, Active A07-11G Kinase Assay, Western Blot View ALK4, Active
Enzymes BMPR2, Active B06-11H Kinase Assay, Western Blot View BMPR2, Active
Signaling Proteins ALK7 Protein A08-35G Western Blot View ALK7 Protein


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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