AMPK (A1/B2/G1) Active Enzymes Active Kinases


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AMPK (A1/B2/G1), Active (P50-10H)
Catalog Number Pack Size Price (USD)  
AMPK (A1/B2/G1), Active P50-10H-05 5 ug $395   AMPK (A1/B2/G1), Active Add to Cart
AMPK (A1/B2/G1), Active P50-10H-10 10 ug $595   AMPK (A1/B2/G1), Active Add to Cart
AMPK (A1/B2/G1), Active P50-10H-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant full-length human AMPK (combination of A1/B2/G1 subunits) was expressed by baculovirus in Sf9 insect cells using a C-terminal His tags.
Tag: His tags
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_006251 , NM_005399 , NM_002733
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~68kDa (A1), ~36kDa (B2), ~40kDa (G1)

Gene Aliases : Subunit A1: PRKAA1, MGC33776, MGC57364 Subunit B2: PRKAB2, MGC61468 Subunit G1: PRKAG1, AMPKG, MGC8666

Scientific Background: AMPK (A1/B2/G1) is a member of the AMPK family which are heterotrimeric proteins consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPKs are an important energy-sensing enzyme group in the cells that monitor energy status particularly in response to stress (1). AMPKs regulate fatty acid and cholesterol synthesis by regulating the key rate-limiting enzymes acetyl-CoA carboxylase and hydroxy beta-methylglutaryl-CoA reductase. The β subunit may be a positive regulator of AMPK activity and is highly expressed in skeletal muscle (2).

References: 
1. Viollet, B. et al: Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models. Biochem. Soc. Trans. 2003; 31; 216–219.

2. Thornton, C. et al: Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. J. Biol. Chem. 273: 12443-12450, 1998.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




AMPK (A1/B2/G1), Active Research Areas

The AMPK (A1/B2/G1), Active product can be utilized in the following research areas, but not limited to:

Apoptosis/Autophagy, Cancer, Cellular Stress, Metabolic Disorder, Ser/Thr Kinases



AMPK (A1/B2/G1), Active Related Products Found: Total 73 Related Products
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Signaling Proteins GSK3 beta, Unactive G09-14G Kinase Assay, Western Blot View GSK3 beta, Unactive
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Signaling Reagents Kinase Assay Buffer I K01-09 Kinase Assay View Kinase Assay Buffer I
Signaling Reagents Kinase Dilution Buffer III K23-09 Kinase Assay View Kinase Dilution Buffer III
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Enzymes MEK1 (EE), Active M02-12G Kinase Assay, Western Blot View MEK1 (EE), Active
Signaling Proteins MEK1, Unactive M02-14H Kinase Assay, Western Blot View MEK1, Unactive
Enzymes MEK2, Active M03-10G Kinase Assay, Western Blot View MEK2, Active
Signaling Proteins MEK2, Unactive M03-14G Kinase Assay, Western Blot View MEK2, Unactive
Enzymes ERK2, Active M28-10G Kinase Assay, Western Blot View ERK2, Active
Signaling Proteins ERK2, Unactive M28-14G Kinase Assay, Western Blot View ERK2, Unactive
Signaling Proteins ERK2, Unactive M28-14U Kinase Assay, Western Blot View ERK2, Unactive
Enzymes ERK1, Active M29-10U Kinase Assay, Western Blot View ERK1, Active
Signaling Proteins ERK1, Unactive M29-14U Kinase Assay, Western Blot View ERK1, Unactive
Enzymes JNK1, Active M33-10G Kinase Assay, Western Blot View JNK1, Active
Signaling Proteins JNK1, Unactive M33-14G Kinase Assay, Western Blot View JNK1, Unactive
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Enzymes PDK1, Active P14-10H Kinase Assay, Western Blot View PDK1, Active
Signaling Reagents PKCtide P15-58 Kinase Assay View PKCtide
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Enzymes PKAc beta, Active P52-10G Kinase Assay, Western Blot View PKAc beta, Active
Enzymes PKAc gamma, Active P53-10G Kinase Assay, Western Blot View PKAc gamma, Active
Enzymes PTPN6 (SHP1), Active P33-20G Phosphatase Assay, Western Blot View PTPN6 (SHP1), Active
Enzymes PTPN11 (SHP2), Active P38-21G Phosphatase Assay, Western Blot View PTPN11 (SHP2), Active
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Enzymes PKC alpha, Active P61-18G Kinase Assay, Western Blot View PKC alpha, Active
Enzymes PKC beta I, Active P62-10G Kinase Assay, Western Blot View PKC beta I, Active
Enzymes PKC beta II, Active P63-10G Kinase Assay, Western Blot View PKC beta II, Active
Enzymes PKC delta, Active P64-10G Kinase Assay, Western Blot View PKC delta, Active
Enzymes PKC epsilon, Active P65-10G Kinase Assay, Western Blot View PKC epsilon, Active
Enzymes PKC gamma, Active P66-10G Kinase Assay, Western Blot View PKC gamma, Active
Enzymes PKC eta, Active P67-10G Kinase Assay, Western Blot View PKC eta, Active
Enzymes PKC iota, Active P68-10G Kinase Assay, Western Blot View PKC iota, Active
Enzymes PKC mu, Active P72-10G Kinase Assay, Western Blot View PKC mu, Active
Enzymes PKC nu, Active P73-10G Kinase Assay, Western Blot View PKC nu, Active
Enzymes PKC zeta, Active P75-10G Kinase Assay, Western Blot View PKC zeta, Active
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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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