Storage, Stability, and Shipping: Store product at –70
oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications: Kinase Assay, Western Blot
Molecular Weight: ~74 kDa
Gene Aliases: CAMKA; KIAA0968
Scientific Background: CAMK2α is a ser/thr protein kinase that is a member of the Ca2+/calmodulin-dependent protein kinase family. CAMK2α is abundant in the brain as a major constituent of the postsynaptic density and is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its Ca2+/calmodulin-dependent activity, CAMK2α can undergo autophosphorylation, resulting in Ca2+/calmodulin-independent activity. The protein level of CAMK2α fluctuates during neuronal activity in cultured rat pup hippocampal neurons. The levels of CAMK2α increased with heightened neuronal activity (2).
References:
1. Silva, A J. et al: Impaired spatial learning in alpha-calcium calmodulin kinase II mutant mice. Science 257: 206-211, 1992.
2. Thiagarajan, T C. et al: Alpha- and beta-CaMKII: inverse regulation by neuronal activity and opposing effects on synaptic strength. Neuron 36: 1103-1114, 2002.
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Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet. |
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Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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The CAMK2 alpha, Active product can be utilized in the following research areas, but not limited to:
Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases
| Product Type |
Product Name |
Catalog Number |
Application |
Pack Sizes |
| Enzymes |
CAMK1 delta, Active |
C09-10G |
Kinase Assay, Western Blot |
View CAMK1 delta, Active
|
| Enzymes |
CAMK1 beta, Active |
C08-10G |
Kinase Assay, Western Blot |
View CAMK1 beta, Active
|
| Enzymes |
CAMK4, Active |
C15-10G |
Kinase Assay, Western Blot |
View CAMK4, Active
|
| Signaling Reagents |
Autocamtide 2 |
A15-58 |
Kinase Assay |
View Autocamtide 2
|
| Signaling Reagents |
Kinase Assay Buffer I |
K01-09 |
Kinase Assay |
View Kinase Assay Buffer I
|
| Enzymes |
CAMKK2, Active |
C18-10G |
Kinase Assay, Western Blot |
View CAMKK2, Active
|
| Enzymes |
CAMK1, Active |
C07-10G |
Kinase Assay, Western Blot |
View CAMK1, Active
|
| Enzymes |
CAMK1 gamma, Active |
C10-11G |
Kinase Assay, Western Blot |
View CAMK1 gamma, Active
|
| Enzymes |
CAMKK1, Active |
C17-10G |
Kinase Assay, Western Blot |
View CAMKK1, Active
|
| Enzymes |
CAMK2 beta, Active |
C12-10H |
Kinase Assay, Western Blot |
View CAMK2 beta, Active
|
| Enzymes |
CAMK2 gamma, Active |
C14-10G |
Kinase Assay, Western Blot |
View CAMK2 gamma, Active
|
| Enzymes |
CAMK2 delta, Active |
C13-10G |
Kinase Assay, Western Blot |
View CAMK2 delta, Active
|
| Signaling Proteins |
Calmodulin 1 Protein |
C01-30H |
Kinase Assay, Western Blot |
View Calmodulin 1 Protein
|
| Signaling Reagents |
Ca2+/Calmodulin Solution, 10x |
C02-39 |
Kinase Assay |
View Ca2+/Calmodulin Solution, 10x
|
| Enzymes |
CAMK1 gamma, Active |
C10-10BG |
Kinase Assay, Western Blot |
View CAMK1 gamma, Active
|